Multiple difficulty levels, replacing Under the Knife's single difficulty level. In remaking Under the Knife for the Wii, numerous changes were made to the game's presentation and gameplay. As the plot progresses, the player is faced with several strains of Gangliated Utrophin Immuno Latency Toxin, or GUILT, a terrorist made viral infection. Standard operations seen early in the game include the removal of tumors and mending severe lacerations. The only major variation in tools is that instead of Derek using his hand to massage a flatlining heart, there is a defibrillator that makes use of the wii's motion controls.Īs in the original game, it is the player's job as Derek Stiles to save the lives of patients by performing operations. The Wii Remote is used to carry out actions on screen such as making incisions, draining blood pools and suturing, while the analogue stick on the Nunchuck is used to easily switch between the available medical tools. The game uses the features of the Wii Remote and Nunchuck in place of the stylus-based gameplay of the DS game. The gameplay in Trauma Center: Second Opinion is very similar to it's predecessor Trauma Center: Under the Knife. 
New "Z-Missions" were added as well, along with a side narrative featuring Nozomi Weaver, a new character that like original protagonist Derek Stiles has the powers of the Healing Touch.
The existing characters were all given a facelift using a new art style. A remake of Atlus's DS title Trauma Center: Under the Knife, the game adapts the original game's stylus-based gameplay to work with the Wii Remote and Nunchuk.
Trauma Center: Second Opinion was released on November 19th, 2006 as a Wii launch title.
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